Divtech Equipment Co.

Micronization and Nanoization of Pharmaceutical Substances

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Pharma Technical Seminar

September 23-24, 2019 Exton Pa

In the “Micronization and Nanonization of Pharmaceutical Substances” seminar, the essential operating parameters of agitator beads mills will be discussed and presented in a logical context. Possible solutions for process optimization will be shown. The process will be considered holistically from cleaning and sterilization to predispersion and micronization, through packaging. How a process developed on a laboratory scale can be transposed to an actual production scale will be discussed.

Topics of Discussion

  • Characterizing the significance of comminuition
  • Terms and Definitions
  • Overview of mixing, wetting, and dispersing processes
  • Overview of NETZSCH grinding systems; agitator bead mills
  • Effect of different process parameters
  • Model of the load energy and number of impacts
  • Effect of the dwell time distribution
  • Griding media selection and scale-up
  • Calculation from laboratory to production scale
  • Limitations of wet grinding
  • True comminution and gentle dispersion
  • Summary and Discussion

For registration details, contact:
Divtech Equipment Co
513-941-0483
info@divtechequipment.com

Please view the attached flyer for additional details

STATIC AND DYNAMIC SURFACE TENSION KNOWLEDGE TO MITIGATE FORMULATION PROBLEMS

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Each fluid or formulation has a unique molecular fingerprint that is the tangential intermolecular force that keeps the fluid or formulation together, expressed in Dynes/Centimeter (or milliNewtons/Meter). This parameter is the Fluid Surface Tension; the force that keeps the fluid together at any air/fluid interface.. If a pure fluid or formulation (no matter how complex) changes at the molecular level then fluid surface tension changes.

Pure fluids and pure solvents have a single surface tension value called “static” or “equilibrium” surface tension. If the formulation contains “active” additives (such as surfactants or contaminants), then the formulation will have a “dynamic” surface tension; a dynamic “fingerprint” of surface tension versus surface age; surface age being the amount of time the process allows surfactant molecules in solution to migrate to any newly created air/fluid interface, where their purpose is to lower the surface tension.

If any pure fluid or formulation changes at the molecular level, then both the static surface tension or dynamic surface tension, respectively, will change. If anything contaminates the fluid in question then the molecular fingerprint will change

Surface tension dictates whether a formulation will wet and spread over, or retract from, a solid substrate. Any formulation exhibits both an adhesive force that is a measurement of the degree of association of the formulation for the substrate, and a cohesive force that is a measure of the degree of self-adhesion of the formulation. Spreading coefficient is the difference between work of adhesion and work of cohesion. If work of adhesion is greater than work of cohesion then spontaneous spreading occurs. If work of cohesion is greater than work of adhesion, then retraction occurs as the formulation will preferentially associate with itself.

It is very essential, that formulators have a good understanding of the principles and relationships of surface tension, and surface energy or “wetting tension”. They must control fluid transfer and adhesion by developing formulations that perform well under widely varying application speeds and operating conditions.

Konica Minolta Sensing – Upcoming Seminars

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About Our Seminars

Join Konica Minolta Sensing for a seminar on the evaluation and control of product color.

Color & Appearance seminars cover the fundamentals of color science and the elements to an effective color process within research and manufacturing environments. These educational seminars are attended by industry professionals with job functions in controlling the color quality, consistency, and appearance of their products or samples. Hosted by a Konica Minolta Sensing color expert, each attendee will leave with a solid understanding of color and the components required for evaluating, communicating, and controlling color internally or throughout the supply chain to meet standards and organizational goals more efficiently.

At the end of the seminar, attendees are encouraged to interact with our experts for technical advice, tips, color and appearance assessments, and networking to stay connected after the event. If interested in having our expert assess the color and appearance of your product or application, please bring in a sample to the seminar.

Upcoming Seminars

Hilton Lexington Downtown 309 West Vine Street Lexington, KY 40507
Date: July 18, 2018 Time: 9:00 AM – 12:00 PM

Konica Minolta Conference Center at SunTrust Park
755 Battery Avenue Southeast Atlanta, GA 30339
Date: August 8, 2018 Time: 9:30 AM – 12:30 PM

Plainridge Park Casino 301 Washington Street Plainville, MA 02762
Date: September 12, 2018 Time: 9:00 AM – 12:00 PM

Registration

Register Here

Konica Minolta Sensing Color & Appearance Seminar 2018

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As with many technical areas, the development and education of color auditors help technicians and operators avoid making mistakes that result from their lack of information and knowledge but they also help the company increase employee retention, gain their loyalty, and ultimately boost organizational productivity. We along with Konica Minolta Sensing America host Color & Appearance Seminars within our region. Please click the link below to learn more and register without cost to participate in these valuable programs:

https://promo.sensing.konicaminolta.us/color-and-appearance-workshops

Dates in our Region:

National Underground Railroad Freedom Center
Tuesday, June 5, 2018
50 East Freedom Way
Cincinnati, OH 45202
9:00AM – 12:00PM